Acquisition of Contextual Discrimination Involves the Appearance of a Ras-GRF1/p38 Map Kinase- Mediated Signaling Pathway that Promotes LTP
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چکیده
Background: The ability to distinguish similar experiences is a critical aspect of memory. Results: Contextual discrimination involves LTP promoted by calcium-permeable AMPA-type glutamate receptors, Ras-GRF1 and p38 Map kinase. Conclusion: A newly discovered, LTP-supporting, signaling pathway contributes to a key component of memory formation. Significance: Defects in this signaling pathway may contribute to cognitive loss associated with neurological disorders.
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تاریخ انتشار 2013